This past Monday, Republican U.S. Senator Ron Johnson of Wisconsin held a panel discussion titled, COVID 19: A Second Opinion. He was joined by a group of world renowned doctors and medical experts that presented a different perspective on the global pandemic response. They shared their thoughts concerning the current state of knowledge of early and hospital treatment, vaccine efficacy and safety, what went right, what went wrong, what should be done now, and what needs to be considered in the long term. This edition of Crosstalk was part 2 of this two-day look at the discussion.